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wehl_ilona

MA Ilona Wehl

C2
Group: Prof. Dr. Ute Schepers
Room: CN/ B305/ R224
Phone: 22715
ilona wehlZog8∂kit edu


Institut für Toxikologie und Genetik und Institut für Angewandte Biowissenschaften
Hermann-von-Helmholtz-Platz 1
Postfach 3640
76021 Karlsruhe



Combinatorial synthesis and high-throughput microscopy of cell penetrating peptoids to isolate organ specific transporters

ilona
Combinatorial synthesis and high-throughput microscopy of cell penetrating peptoids to isolate organ specific transporters
Project Group:

Project are C, project C2

Links:
Startdate:

03/2016

The development of pharmacologically active compounds is rapidly growing and a great progress in the treatment of many diseases has been made. However, several drugs lack of specificity to their target tissue, leading to poor efficiency and increased cytotoxicity to the healthy surrounding tissue. Furthermore, treatments options for diseases of the central nervous system, such as Parkinson’s and Alzheimer’s, are still poor. Drug delivery systems can ensure an organ-specific transport, even with the brain as target tissue, and simultaneously decrease the cytotoxicity of therapeutic agents.
We are investigating cell-penetrating peptoids as organelle- and organ-specific carrier molecules. Peptoids mimic the structure of their peptidic counterparts, by maintaining the ability to penetrate cells, but display increased stability in vivo. Fluorescent labeling of peptoids provides the possibility for microscopic analysis of cellular uptake and organ-specific localization in zebrafish larvae as model organism. We develop and evaluate high-throughput approaches for the screening and evaluation of large and diverse peptoid libraries to elucidate structure-function relationships and identify specific carrier molecules.