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Tim Schober

MSc. Tim Schober

Group: Prof. Ulrich
Room: CS / IOC / R 501
Phone: 47223
tim schoberTxm2∂kit edu



Photoswitchable bioactive peptidomimetics

Photoswitchable bioactive peptidomimetics
Project Group:

Projectarea B, project B2

Links:
Startdate:

02/2017

Tim Schober was born in 1991 in Worms, Germany. He studied Chemical Biology at the Karlsruhe Institute of Technology (KIT) with the focus on organic and peptide synthesis. He graduated (M.Sc.) in 2017. He is currently pursuing his PhD at the KIT in the group of Prof. Anne Ulrich.

His work focuses on photoswitchable bioactive peptidomimetics. He is part of the DFG-funded graduate school „GRK2039 – Molecular Architectures for Fluorescent Cell Imaging“. His contribution is the development of photocontrollable cell-penetrating peptides, based on diarylethene amino acids, that can serve for targeting and imaging.

Publications:

[1]      
Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties.
M. J. Klein, S. Schmidt, P. Wadhwani, J. Bürck, J. Reichert, S. Afonin, M. Berditsch, T. Schober, R. Brock, M. Kansy, et al.,
J. Med. Chem. 201760, 8071–8082.
 
[2]      
Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers.
O. Babii, S. Afonin, T. Schober, I. V. Komarov, A. S. Ulrich,
Biochim. Biophys. Acta - Biomembr. 20171859, 2505–2515.
 
[3]      
Efficiently Photocontrollable or Not? Biological activity of Photoisomerizable Diarylethenes.
I. V. Komarov, S. Afonin, O. Babii, T. Schober, A. S. Ulrich,
Chem. Eur. J. 201824, 1–11.