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MA Sophina Christ

PhD Student
Group: Prof. Niemeyer
Room: CN / B 601
Phone: 26566
Fax: +49 721 608-925546
sophina christWqg7∂kit edu

Karlsruher Institut für Technologie (KIT)

Institut für Biologische Grenzflächen 1

Hermann-von-Helmholtz-Platz 1

Multi-Scale DNA Origami Structures to Study Early Cell Signaling in Mast Cells

Multi-Scale DNA Origami Structures to Study Early Cell Signaling in Mast Cells

Sophina Christ

Project Group:




Membrane receptor proteins are key elements in the interactions between cells and their environment. Upon binding their cognate ligands, receptors initiate a cascade of signaling events inside the cell, which ultimately determine a final cell response. In order to analyze these signaling events as a function of the spatial arrangement of ligands, interdisciplinary technology solutions are required, which enable control over number, stoichiometry, and precise nanoscale orientation of ligands. We apply DNA origami-based nanostructures to create surface-bound ligand architectures that comprise a lateral resolution of different ligands with distances in the typical range of biomolecular assemblies (~5-100 nm).[1] In this project we strive to use this technology for the investigation of receptor activation and recruitment of downstream signaling components in mast cells.



[1]        A. Angelin, S. Weigel, R. Garrecht, R. Meyer, J. Bauer, R. K. Kumar, M. Hirtz, and C. M. Niemeyer, 'Multiscale Origami Structures as Interface for Cells', Angew Chem Int Ed Engl, 54 (2015), 15813-7.