Sabljo Kristina Sabljo

MSc. Kristina Sabljo

Synthesis and Characterization of Inorganic-organic Hybrid Nanoparticles for Biomedical Applications

  • Contact:

    Kristina Sabljo

  • Project Group:

    C2

  • Startdate:

    11/2019

Multifunctional inorganic-organic hybrid nanoparticles (IOH-NPs) represent a novel concept of nanomaterials for biomedical application. IOH-NPs consist of equimolar amounts of an inorganic cation (e.g. [ZrO]2+ , [Gd]3+ ) and a functional organic anion [RFunctionOPO3]2- or [RFunctionSO3]- (RFunction: functional organic group). Through the functional organic anion specific functions such as fluorescence ([RDyeOPO3]2-, [RDyeSO3]-) or therapeutic activity ([RDrugOPO3]2- or [RDrugSO3]-) can be introduced. Such nanoparticles are characterized by a straightforward aqueous synthesis, low material complexity, high load of functional organic anion (70-80 wt-%) and high cell uptake at low toxicity. The integration of a fluorescent dye into therapeutically active hybrid nanoparticles gives the option to trace them in vitro and in vivo and to image the tissue of accumulation. The overall aim of the project is to amplify the material concept to new therapeutic agents. In contrast to free drug application, the IOH-NPs should show a higher therapeutic efficiency, improved selective accumulation and less side effects.